PHR1106
L-アルギニン
Pharmaceutical Secondary Standard; Certified Reference Material
別名:
(S)-2-アミノ-5-グアニジノペンタン酸
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この商品について
化学式:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
CAS番号:
分子量:
174.20
NACRES:
NA.24
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
41116107
EC Number:
200-811-1
MDL number:
Beilstein/REAXYS Number:
1725413
製品名
L-アルギニン, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI key
ODKSFYDXXFIFQN-BYPYZUCNSA-N
SMILES string
N[C@@H](CCCNC(N)=N)C(O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. A1270000
traceable to USP 1042500
API family
arginine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
222 °C (dec.) (lit.)
application(s)
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Biochem/physiol Actions
一酸化窒素シンターゼの基質で、シトルリンと一酸化窒素(NO)に転換されます。一酸化窒素依存的な機序によってインスリンの放出を誘導します。
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-Arginine is a dibasic, semi-essential amino acid. It acts as a precursor for creatinine and is a natural constituent of most of the dietary proteins. It also plays a key role in many physiological processes such as tissue repair and reproduction.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7157 in the slot below. This is an example certificate only and may not be the lot that you receive.
保管分類
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Diane N Singhroy et al.
Retrovirology, 10, 73-73 (2013-07-23)
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e.
Palaniraja Thandapani et al.
Molecular cell, 50(5), 613-623 (2013-06-12)
Motifs rich in arginines and glycines were recognized several decades ago to play functional roles and were termed glycine-arginine-rich (GAR) domains and/or RGG boxes. We review here the evolving functions of the RGG box along with several sequence variations that
Ahmed Moursy et al.
Nucleic acids research, 42(10), 6659-6672 (2014-04-03)
Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited
John Pernow et al.
Cardiovascular research, 98(3), 334-343 (2013-02-19)
Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric oxide (NO). Recently, the enzyme arginase has emerged as an important regulator of NO production
Hartmut Grasemann et al.
Current pharmaceutical design, 18(5), 726-736 (2012-01-11)
The concentrations of nitric oxide are decreased in airways of patients with cystic fibrosis. The reasons for this nitric oxide deficiency are incompletely understood but may include reduced production from nitric oxide synthases due to decreased expression, the enzymes in
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