S7882

(−)-Scopolamine N-butyl bromide

Name: (−)-Scopolamine N-butyl bromide
Brand: SIGMA

≥98% (TLC), powder

別名:

(−)-N-Butylscopolamine bromide, Hyoscine N-butyl bromide

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この商品について

実験式（ヒル表記法）:

C₂₁H₃₀BrNO₄

CAS番号:

149-64-4

分子量:

440.37

NACRES:

NA.77

PubChem Substance ID:

24277872

UNSPSC Code:

12352116

EC Number:

205-744-1

MDL number:

MFCD00078561

Assay:

≥98% (TLC)

Form:

powder

Quality level:

100

主要文書

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InChI key

HOZOZZFCZRXYEK-GSWUYBTGSA-M

InChI

1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1

SMILES string

[Br-].[H][C@@]12C[C@H](C[C@@]([H])([C@]3([H])O[C@]13[H])[N+]2(C)CCCC)OC(=O)[C@H](CO)c4ccccc4

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D −20.8°, c = 3 in H₂O(lit.)

color

white

solubility

H₂O: 50 mg/mL

Quality Level

100

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Application

(−)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.⁸

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.⁵ The central effects include hallucinations, disorientation, restlessness and euphoria.⁶ Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.⁷

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332

pcodes

P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

S7882-5G: + S7882-VAR: + S7882-BULK: + S7882-1G:

jan

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Quantification in capillary electrophoresis-mass spectrometry: long- and short-term variance components and their compensation using internal standards.

Jens Ohnesorge et al.

Electrophoresis, 26(12), 2360-2375 (2005-06-01)

Different approaches were chosen to examine ionization reproducibility of analytes after separation by capillary electrophoresis-mass spectrometry (CE-MS) in a commercially available sheath-flow electrospray interface. For this task three different standard samples were examined. Sample 1 contained neostigmine bromide (cationic), paracetamol

Inhibitory effects of various spasmolytics on the vagal afferent gastric excitatory response in cats.

K Kurahashi et al.

Life sciences, 61(8), 831-838 (1997-01-01)

The inhibitory effects of atropine, cimetropium, pirenzepine and N-butylscopolamine on the vagal afferent gastric excitatory response in cats under anesthesia with pentobarbital sodium and infusion of gallamine were examined. Electrical stimulation of vagal trunk in left side (10 Hz in

Expression of muscarinic receptor subtypes in rat gastric smooth muscle: effect of M3 selective antagonist on gastric motility and emptying.

S Lin et al.

Digestive diseases and sciences, 42(5), 907-914 (1997-05-01)

Expression of muscarinic receptor subtypes in rat gastric smooth muscle was examined with reverse transcriptase-polymerase chain reaction (RT-PCR). Under the condition for detecting the messages of m1-m4 subtypes in brain, atrium, and gastric mucosa, only the fragments of m2 and

Colon distension, perceived burden and side-effects of CT-colonography for screening using hyoscine butylbromide or glucagon hydrochloride as bowel relaxant.

Margriet C de Haan et al.

European journal of radiology, 81(8), e910-e916 (2012-06-12)

Compare colonic distension and perceived burden of CT-colonography between participants receiving hyoscine butylbromide (buscopan) and glucagon hydrochloride as bowel relaxant. Data were collected within a screening trial. Participants received 20mg buscopan intravenously or 1mg of glucagon intravenously (if buscopan contra-indicated).

Myometrial response to neurotropic and musculotropic spasmolytic drugs in an extracorporeal perfusion model of swine uteri.

J Künzel et al.

Reproductive biomedicine online, 23(1), 132-140 (2011-07-16)

To compare the effects of neurotropic and musculotropic spasmolytic drugs in isolated swine uterus specimens, 80 swine uteri were perfused using an established model for preserving a viable organ that responds to oxytocic hormones and spasmolytic drugs. An intrauterine catheter

(−)-Scopolamine N-butyl bromide

≥98% (TLC), powder

サイズを選択してください

この商品について

主要文書

特性

InChI key

InChI

SMILES string

assay

form

optical activity

color

solubility

Quality Level

Gene Information

詳細

Application

Biochem/physiol Actions

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

S7882-5G: + S7882-VAR: + S7882-BULK: + S7882-1G:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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