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580549

Tauroursodeoxycholic Acid, Sodium Salt

Name: Tauroursodeoxycholic Acid, Sodium Salt
Brand: MM

Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

Synonym(s):

Tauroursodeoxycholic Acid, Sodium Salt, Sodium Tauroursodeoxycholate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₄₄NO₆S · Na

CAS Number:

35807-85-3

Molecular Weight:

521.69

MDL number:

MFCD31725069

UNSPSC Code:

12352106

NACRES:

NA.21

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Properties

description

RTECS - KI7372500

Quality Segment

100

assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

15-25°C

SMILES string

[S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1

InChI key

BHTRKEVKTKCXOH-AYSJQVDDSA-N

Description

General description

Detergent useful for the solubilization of lipids and membrane-bound proteins. Has cryoprotective effects against hydrophobic bile salts in rats. Also reported to inhibit pepsin activity in vitro.

Application

Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.: This study highlights the efficacy of tauroursodeoxycholic acid, sodium salt in reducing endoplasmic reticulum stress, suggesting its utility in preventing vascular complications in diabetes (Gaikwad AB et al., 2022).

Other Notes

Ozcan, U., et al. 2006. Science313, 1137.
Miyake, H., et al. 1999. Dig. Dis. Sci.44, 197.
Eto, T. and Tompkins, R.K. 1985. Am. J. Surg.150, 564.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c