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P9375

1,10-Phenanthroline monohydrate

Name: 1,10-Phenanthroline monohydrate
Brand: SIAL

reagent grade

Synonym(s):

o-Phenanthroline monohydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₈N₂ · H₂O

CAS Number:

5144-89-8

Molecular Weight:

198.22

UNSPSC Code:

12352116

NACRES:

NA.77

PubChem Substance ID:

24278663

EC Number:

200-629-2

Beilstein/REAXYS Number:

4008096

MDL number:

MFCD00149973

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Properties

biological source

synthetic (organic)

Quality Level

200

grade

reagent grade

form

powder

mp

100-104 °C (lit.)

solubility

methanol: 200 mM (Stock solution is stable for months at –20° C.)

SMILES string

O.c1cnc2c(c1)ccc3cccnc23

InChI

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

InChI key

PPQJCISYYXZCAE-UHFFFAOYSA-N

Gene Information

human ... FNTA(2339)

Description

General description

Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.

Application

1,10-Phenanthroline monohydrate has been used:

as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
as a negative control in in situ zymography of mice heart samples
in in vitro resveratrol chelation and reducing activities assays to chelate iron

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.