P5899
Poly-ʟ-Lysine Hydrobromide
synthetic, mol wt ≥300,000, powder, γ-irradiated, suitable for cell culture, BioXtra
동의어(들):
PLL HBr
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제품정보 (DICE 배송 시 비용 별도)
CAS 번호:
UNSPSC Code:
12352202
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.75
MDL number:
Biological source:
synthetic (organic)
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
≥300,000
제품 이름
Poly-L-lysine hydrobromide, mol wt ≥300,000, lyophilized powder, γ-irradiated, BioXtra, suitable for cell culture
biological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
mol wt
≥300,000
packaging
pkg of 5 mg
technique(s)
cell culture | mammalian: suitable
surface coverage
4 μg/cm2
impurities
<10% water (by Karl Fischer)
solubility
H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
−20°C
SMILES string
Cl.NCCCCC(N)C(O)=O
InChI
1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1
InChI key
WBSCNDJQPKSPII-KKUMJFAQSA-N
Application
Poly-L-lysine hydrobromide has been used to coat:
- 2-well plates before seeding muscle cells in a research study on rainbow trout myotube formation
- flat bottom 96-well plates for in vitro neuronal stem cell differentiation
- T75 flasks for primary astrocytic cultures
Biochem/physiol Actions
Poly-L-lysine serves as a coating substance to ensure better attachment of cells to culture surfaces. Research shows that plates coated with poly-L-lysine (PLL) demonstrated an accelerated cell growth rate. Culturing mesenchymal stem cells (MSCs) on PLL-coated substrates has been found to safeguard the stemness properties of these cells and inhibit senescence. PLL-coated plates have demonstrated enhanced MSC growth and up-regulated the expression of genes associated with cell adhesion, differentiation, proliferation, and signaling. Moreover, porous PLL-coated surfaces have shown improvements in cell proliferation and the osteogenic differentiation of MSCs.
Analysis Note
Molecular weight based on viscosity. Also assayed by MALLS.
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Poly-L-lysine is a positively charged amino acid polymer with approximately one HBr per lysine residue. The hydrobromide allows the poly-L-lysine to be in a crystalline form soluble in water. A small amount of product may be found in the beta structure because the HBr interferes with hydrogen bonding between amino and either the carboxyl groups or N or O containing moieties.
Disclaimer
Sterile solutions are stable for up to 2 years when stored at 2-8°C. It should be stored desiccated at -20°C.
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저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)