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36-008-C

Anti-α-Synuclein (SNCA) Antibody

mouse monoclonal, Syn211

Synonym(s):

Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
Syn211, monoclonal
Species reactivity:
human
Application:
IHC, WB
Citations:
2
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Product Name

Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free), clone Syn211, from mouse

biological source

mouse

Quality Segment

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

Syn211, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_000336

UniProt accession no.

P37840

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)

General description

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson′s disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
~15 kDa observed

Immunogen

Conjugated recombinant protein corresponding to human alpha-Synuclein.
Epitope: alpha-syn 121-125

Application

Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) is an antibody against alpha-Synuclein for use in Immunohistochemistry and Western Blotting.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected alpha-Synuclein in human cerebral cortex and human kidney tissue.
Western Blotting Analysis: A representative lot detected alpha-Synuclein in Synucleinopathy brains (Guo, J.L., et al. (2013). Cell. 154:103-117).

Physical form

Format: Purified

Preparation Note

Stable for 1 year at 2-8°Cfrom date of receipt.

Analysis Note

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected alpha-Synuclein in 10 µg of human brain tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

36-008-C:

jan

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