PHR1375
Ketoprofen
Pharmaceutical Secondary Standard; Certified Reference Material
동의어(들):
Ketoprofen, KP, 2-(3-Benzoylphenyl)propionic acid
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H14O3
CAS 번호:
Molecular Weight:
254.28
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
244-759-8
MDL number:
InChI key
DKYWVDODHFEZIM-UHFFFAOYSA-N
InChI
1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
SMILES string
CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. K2000000, traceable to USP 1356632
API family
ketoprofen
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... PTGS1(5742), PTGS2(5743)
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ketoprofen is an active pharmaceutical compound used as a non-steroidal anti-inflammatory drug (NSAID). It is essentially a non-narcotic drug extensively utilized for mild to moderate pain relief.
Ketoprofen is an active pharmaceutical compound used as a non-steroidal anti-inflammatory drug (NSAID). It is essentially a non-narcotic drug extensively utilized for mild to moderate pain relief.
Application
Ketoprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Non-steroidal anti-inflammatory compound that is selective for COX-1.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3470 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Development and validation of a stability-indicating high-performance liquid chromatographic assay for ketoprofen topical penetrating gel
Bempong DK and Bhattacharyya L
Journal of Chromatography A, 1073(1-2), 341-346 (2005)
UV-spectrophotometric determination of ketoprofen and paraben in a gel preparation by partial least-squares calibration
Blanco M, et al.
Fresenius Journal of Analytical Chemistry, 357(7), 967-972 (1997)
Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals
Dvorak J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(3), 625-629 (2004)
H Bagheri et al.
Drug safety, 22(5), 339-349 (2000-06-01)
The topical use of nonsteroidal anti-inflammatory drugs (NSAIDs), widely used for moderate acute and chronic painful conditions, is one of several strategies used to improve the tolerability profile of NSAIDs, particularly with regard to gastric and renal adverse effects. However
M Sugiura et al.
Contact dermatitis, 43(1), 16-19 (2000-07-21)
We report 4 cases of photocontact dermatitis due to ketoprofen, a non-steroidal anti-inflammatory drug derived from propionic acid. We carried out a skin biopsy to examine the amount of ketoprofen in the eruptive skin. We investigated the cross-reactions between tiaprofenic
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