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Merck

N8129

β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

≥97% (HPLC)

동의어(들):

β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C21H27N7Na2O14P2 · xH2O
CAS 번호:
606-68-8
Molecular Weight:
709.40 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
329818676
UNSPSC Code:
41106305
EC Number:
210-123-3
MDL number:
MFCD03791273
Form:
powder
Assay:
≥97% (HPLC), ≥97% (spectrophotometric assay)
Solubility:
water: 712 g/L at 22.5 °C, 10 mM NaOH: soluble-100 mg/mL, clear to slightly hazy, faintly yellow to greenish-yellow
Biological source:
yeast
Color:
white to light yellow

주요 문서

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InChI key

FWBNCIFELNNJCX-UHOVGGJYSA-L

InChI

1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1

SMILES string

O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

biological source

yeast

assay

≥97% (HPLC), ≥97% (spectrophotometric assay)

form

powder

Quality Level

300

mol wt

709.40 g/mol

color

white to light yellow

solubility

water: 712 g/L at 22.5 °C, 10 mM NaOH: soluble-100 mg/mL, clear to slightly hazy, faintly yellow to greenish-yellow

density

1.995 g/cm3 at 20 °C

storage temp.

−20°C

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관련 카테고리

Application

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Packaging

Packaged by solid weight.

저장 등급

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
SLCF1867
SLCD5502
SLCG9423
SLCB5013
SLBW8621

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NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with impaired electron transport chain activity, NADH accumulation can be toxic. To minimize such toxicity, elevated NADH inhibits the classical NADH-producing pathways: glucose, glutamine, and fat oxidation.
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문서

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Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

프로토콜

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Spectrophotometric assay evaluates malic dehydrogenase activity using bovine heart enzyme with critical histidine residue at active site.

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