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Merck

1134368

USP

Citric acid

United States Pharmacopeia (USP) Reference Standard

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
HOC(COOH)(CH2COOH)2
CAS 번호:
77-92-9
Molecular Weight:
192.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749410
MDL number:
MFCD00011669
Beilstein/REAXYS Number:
782061

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InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

citric acid

form

crystalline

expl. lim.

8 %, 65 °F

manufacturer/tradename

USP

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

solubility

water: 383 g/L at 25 °C

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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관련 카테고리

General description

Citric acid is a weak organic acid naturally found in citrus fruits. It is widely used as an acidulant, preservative, and flavoring agent in the food and pharmaceutical industries.​ In pharmaceutical formulations, citric acid acts as a buffering agent to control pH and enhance the stability of active ingredients. The USP Citric Acid standard ensures the consistency and quality of citric acid used in these applications.The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

Citric acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Anhydrous Citric Acid
  • Citric Acid Monohydrate
  • Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution
  • Monoglyceride Citrate
  • Powdered Garcinia Hydroxycitrate Extract
  • Anticoagulant Citrate Phosphate Dextrose Solution
  • Potassium Citrate Extended-Release Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 2711-2711 (2018)
Powdered Garcinia Hydroxycitrate Extract
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 36(3), 5014-5014 (2020)
Calcium Citrate Malate
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(2), 694-694 (2018)
Monoglyceride Citrate
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 30(6), 5891-5891 (2018)
Giampiero Rossi-Fedele et al.
Journal of endodontics, 38(4), 426-431 (2012-03-15)
Root canal irrigants play a significant role in the elimination of microorganisms, tissue dissolution, and the removal of debris and smear layer. No single solution is able to fulfill these actions completely; therefore, their association is required. The aim of
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