491207
Novobiocin sodium salt
≥90% (HPLC), powder, DNA gyrase inhibitor, Calbiochem®
동의어(들):
Novobiocin, Sodium Salt
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C31H35N2O11 · Na
CAS 번호:
Molecular Weight:
634.61
MDL number:
UNSPSC Code:
51286504
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
제품 이름
Novobiocin, Sodium Salt,
assay
≥90% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to yellow
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].N([C-]2C(=O)Oc3c(ccc(c3C)OC4OC(C(C(C4O)OC(=O)N)OC)(C)C)C2=O)C(=O)c1cc(c(cc1)O)CC=C(C)C
InChI
1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
InChI key
AXOUUAINTJNFRS-UHFFFAOYSA-N
General description
A DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
Biochem/physiol Actions
Cell permeable: no
Primary Target
retrovirus RNA-dependent DNA polymerases
retrovirus RNA-dependent DNA polymerases
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
Other Notes
Marcu, M.G., et al. 2000. J. Natl. Cancer Inst.92, 242.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp.42, 1911.
Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable