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PHR1353

エストラジオール

Name: エストラジオール
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

β-エストラジオール, 1,3,5-エストラトリエン-3,17β-ジオール, 17β-エストラジオール, 3,17β-ジヒドロキシ-1,3,5(10)-エストラトリエン, ジヒドロフォリクリン

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この商品について

実験式（ヒル表記法）:

C₁₈H₂₄O₂

CAS番号:

50-28-2

分子量:

272.38

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823337

EC Number:

200-023-8

Beilstein/REAXYS Number:

1914275

MDL number:

MFCD00003693

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特性

Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1250008, traceable to Ph. Eur. E1620000

API family

estradiol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099)

詳細

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Estradiol is a steroid hormone present naturally in the human body. The availability of this hormone is quintessential in older women as it is a determinant of menopausal syndromes. It is utilized for the prevention of cardiovascular diseases.

Application

Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

閉経前に卵巣から分泌される主要なエストロゲンです。

閉経前に卵巣から分泌される主要なエストロゲンです。エストロゲンは、遺伝子転写によるタンパク合成を調節することにより、胚発生期や思春期におけるメス表現型の発達を誘導します。また、ゴナドトロピン産生を促すことにより排卵を誘発します。エストラジオールへの曝露は乳癌の発生率や増殖を増強します。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3704 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08,GHS09

signalword

Danger

hcodes

H351,H360FD,H362,H410

pcodes

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c