T144
(±)-Thalidomide
≥98%, beta-secretase inhibitor, powder
동의어(들):
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C13H10N2O4
CAS 번호:
Molecular Weight:
258.23
UNSPSC Code:
12352111
eCl@ss:
39180303
PubChem Substance ID:
NACRES:
NA.77
EC Number:
200-031-1
MDL number:
Assay:
≥98%
Form:
powder
제품 이름
(±)-Thalidomide, ≥98%, powder
ligand
thalidomide
Quality Segment
assay
≥98%
form
powder
reaction suitability
reagent type: ligand
color
white
solubility
DMSO: 20 mg/mL, clear
originator
Celgene
SMILES string
O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
InChI
1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChI key
UEJJHQNACJXSKW-UHFFFAOYSA-N
Gene Information
human ... CRBN(51185), CUL4A(8451), DDB1(1642), LITAF(9516), RBX1(9978), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)
Application
Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.
Biochem/physiol Actions
(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.
Features and Benefits
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges