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07-896 Anti-phospho-Rac1/cdc42 (Ser71) Antibody

Anti-phospho-Rac1/cdc42 (Ser71) Antibody detects level of phospho-Rac1/cdc42 (Ser71) & has been published & validated for use in WB.

Anti-phospho-Rac1/cdc42 (Ser71) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: RAC1, ORFNames=MIG5, TC-25, p21-Rac1, MGC111543, PAK1, MIG5 UniProt Number: P63000
07-896
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-896
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Rac1/cdc42 (Ser71) Antibody
      References
      Product Information
      FormatAffinity Purified
      Applications
      ApplicationAnti-phospho-Rac1/cdc42 (Ser71) Antibody detects level of phospho-Rac1/cdc42 (Ser71) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Rac1/cdc42 (Ser71).
      HostRabbit
      SpecificityRecognizes phosphorylated Rac1/cdc42 (Ser71)
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NotePredicted to cross react with mouse based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
      Gene Symbol
      • RAC1
      • ORFNames=MIG5
      • TC-25
      • p21-Rac1
      • MGC111543
      • PAK1
      • MIG5
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P63000 # Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
      SIZE: 192 amino acids; 21450 Da
      SUBUNIT: Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2.
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      TISSUE SPECIFICITY: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
      DOMAIN: SwissProt: P63000 The effector region mediates interaction with DEF6.
      SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      07-896 04053252672668

      Documentation

      Anti-phospho-Rac1/cdc42 (Ser71) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-Rac1/cdc42 (Ser71) (Affinity - DAM1767461 DAM1767461
      Anti-phospho-Rac1/cdc42 (Ser71) (Affinity purified Rabbit polyclonal IgG) - DAM1432890 DAM1432890
      Anti-phospho-Rac1/cdc42 (Ser71) (Affinity purified Rabbit polyclonal IgG) - NG1926734 NG1926734
      Anti-phospho-Rac1/cdc42 (Ser71) - 0604027405 0604027405
      Anti-phospho-Rac1/cdc42 (Ser71) - DAM1479595 DAM1479595
      Anti-phospho-Rac1/cdc42 (Ser71) - DAM1805217 DAM1805217
      Anti-phospho-Rac1/cdc42 (Ser71) - DAM1812777 DAM1812777

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies