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260920 DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I

Primary Target: CPG methylase M.Sssl
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260920
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
32675-71-1C₁₉H₁₄N₂O₄

Precios y disponibilidad

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260920-10MG
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      Description
      OverviewA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
      Catalogue Number260920
      Brand Family Calbiochem®
      Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
      References
      ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.
      Product Information
      CAS number32675-71-1
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₄N₂O₄
      Chemical formulaC₁₉H₁₄N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetCPG methylase M.Sssl
      Primary Target IC<sub>50</sub>115 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      260920-10MG 04055977217520

      Documentation

      DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      260920

      Referencias bibliográficas

      Visión general referencias
      Brueckner, B., et al. 2005. Cancer Res. 65, 6305.

      Licencias necesarias e Información técnica

      Cargo
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      Synonyms2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
      DescriptionA cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number32675-71-1
      Chemical formulaC₁₉H₁₄N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBrueckner, B., et al. 2005. Cancer Res. 65, 6305.