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373225 Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V

Primary Target: ubiquitination of p53 in vitro
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      414905-09-2C₁₀H₈F₆N₂O₃S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
      Catalogue Number373225
      Brand Family Calbiochem®
      SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
      References
      ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
      Product Information
      CAS number414905-09-2
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₀H₈F₆N₂O₃S
      Chemical formulaC₁₀H₈F₆N₂O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary Targetubiquitination of p53 in vitro
      Primary Target IC<sub>50</sub>12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      373225 0

      Documentation

      Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      373225

      Referencias bibliográficas

      Visión general referencias
      Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2014 JSW
      SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
      DescriptionA cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number414905-09-2
      Chemical formulaC₁₀H₈F₆N₂O₃S
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.