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420345 Kaempferol - CAS 520-18-3 - Calbiochem

A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells.

Kaempferol - CAS 520-18-3 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3,4ʹ,5,7-Tetrahydroxyflavone

Primary Target: Topoisomerase I-catalyzed DNA religation in HL-60 cells
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420345
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
520-18-3C₁₅H₁₀O₆

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
420345-25MG
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      Description
      OverviewA cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
      Catalogue Number420345
      Brand Family Calbiochem®
      Synonyms3,4ʹ,5,7-Tetrahydroxyflavone
      References
      ReferencesWang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
      Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
      Wang, H., et al. 2000. Phytomedicine 7, 15.
      Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
      Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
      Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
      Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.
      Product Information
      CAS number520-18-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₀O₆
      Chemical formulaC₁₅H₁₀O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality SegmentMQ100
      Applications
      Biological Information
      Primary TargetTopoisomerase I-catalyzed DNA religation in HL-60 cells
      Primary Target IC<sub>50</sub>180 µM against COX-1 activity
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLK9275200
      Safety Information
      R PhraseR: 36/37/38-40

      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Número de referencia GTIN
      420345-25MG 04055977187502

      Documentation

      Licencias necesarias

      Título
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Kaempferol - CAS 520-18-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Kaempferol - CAS 520-18-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      420345

      Referencias bibliográficas

      Visión general referencias
      Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
      Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
      Wang, H., et al. 2000. Phytomedicine 7, 15.
      Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
      Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
      Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
      Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.

      Folleto

      Cargo
      Alzheimer's Disease Brochure & Technical Guide
      Caspases and other Apoptosis Related Tools Brochure
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-January-2008 JSW
      Synonyms3,4ʹ,5,7-Tetrahydroxyflavone
      DescriptionA cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number520-18-3
      RTECSLK9275200
      Chemical formulaC₁₅H₁₀O₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 5274
      ReferencesWang, C.N., et al. 2001. J. Biol. Chem. 276, 5287.
      Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451.
      Wang, H., et al. 2000. Phytomedicine 7, 15.
      Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945.
      Roth, A., et al. 1999. J. Neurosci. Res. 57, 399.
      Boege, F., et al. 1996. J. Biol. Chem. 271, 2262.
      Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.