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AB15644 Anti-HuD Antibody

This Anti-HuD Antibody is validated for use in WB for the detection of HuD.

Anti-HuD Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience, Neuronal & Glial Markers Gene Symbol: HUD, PNEM , ELAVL4 , OTTHUMP00000009612 UniProt Number: P26378
AB15644
100 µg  
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      Overview

      Replacement Information
      Replacement InformationAB05644 is a recommended replacement for AB5971

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15644
      ReplacesAB5971
      DescriptionAnti-HuD Antibody
      Alternate Names
      • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
      • ELAV-like 4
      • Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4
      • Hu-antigen D
      • Paraneoplastic encephalomyelitis antigen HuD
      Background InformationELAV-like protein 4 (ELAVL4) also know as Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and consists of two N-terminal RNA recognition motifs (RRM1 and -2), a hinge region, and a C-terminal RRM (RRM3). Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. HuD is localized and expressed in brain tissue immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. HuD has been linked with the disease, paraneoplastic encephalomyelitis sensory neuropathy, which is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities.
      References
      Product Information
      FormatPurified
      Control
      • Human Brain lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4) 15mM sodium chloride with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-HuD Antibody is validated for use in WB for the detection of HuD.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide a.a. 26-42.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody recognizes HuD.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteTested on human, mouse, and rat. Sequence Homology 100% with rat, mouse, human, primate, dog, cow
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HUD
      • PNEM
      • ELAVL4
      • OTTHUMP00000009612
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26378 # May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity).
      SIZE: 380 amino acids; 41760 Da
      SUBUNIT: Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP (By similarity).
      TISSUE SPECIFICITY: Brain.
      PTM: Methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state. Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
      DISEASE: SwissProt: P26378 # Paraneoplastic encephalomyelitis sensory neuropathy is associated with small cell lung cancer and is characterized by dementia, sensory loss, and other neurological disabilities. It may result from an immune response primarily directed against a small cell lung tumor antigen which is misdirected against similar antigens expressed in brain.
      SIMILARITY: SwissProt: P26378 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
      Molecular WeightApprox. 42 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on human brain lysate
      Western Blot:
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      AB15644 04053252672460

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies