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16-111 Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose

Detect MAP Kinase 1/2 (Erk1/2) using this Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose validated for use in IP.

Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: MAPK1, p40, PRKM2, MAPK2, PRKM1, p42-MAPK, p38, p41, ERK, ERK-2, ERT1, P42MAPK, p41mapk, ERK2 UniProt Number: P28482
16-111
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, ChIPMGel ImmobilizedPolyclonal Antibody
      Description
      Catalogue Number16-111
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose
      OverviewAnti-MAP Kinase/Erk 1/2 (06-182) covalently coupled to Protein A agarose by dimethyl-pimelimidate.
      References
      Product Information
      FormatGel Immobilized
      PresentationPBS, pH 7.4 containing 0.05% sodium azide
      Applications
      ApplicationDetect MAP Kinase 1/2 (Erk1/2) using this Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Application NotesSuitable for immunoprecipitation and affinity purification.
      Biological Information
      HostMouse
      Species Reactivity
      • Human
      • Mouse
      • Chicken
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
      Gene Symbol
      • MAPK1
      • p40
      • PRKM2
      • MAPK2
      • PRKM1
      • p42-MAPK
      • p38
      • p41
      • ERK
      • ERK-2
      • ERT1
      • P42MAPK
      • p41mapk
      • ERK2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
      COFACTOR: Magnesium (By similarity).
      SIZE: 360 amino acids; 41390 Da
      SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
      DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
      PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
      SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitating MAP Kinase/Erk 1/2 from a RIPA lysate of 3T3/A31 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      16-111 04053252322471

      Documentation

      Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MAP Kinase 1/2 (Erk1/2) Antibody, agarose Certificates of Analysis

      TitleLot Number
      Anti-Kv4.2 - DAM1518887 DAM1518887
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 14961 14961
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 17169 17169
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 17716 17716
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 19048 19048
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 20719 20719
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 21054 21054
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 21659 21659
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 22904 22904
      Anti-MAP Kinase 1/2 (Erk1/2), agarose - 27644 27644
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies