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05-1346 Anti-PRDM12 Antibody, clone 49AT1111.91.20

Anti-PRDM12 Antibody, clone 49AT1111.91.20 is a Mouse Monoclonal Antibody for detection of PRDM12 also known as PR-domain zinc finger protein 12 & has been validated in ELISA & WB.

Anti-PRDM12 Antibody, clone 49AT1111.91.20 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: PFM9, OTTHUMP00000022367 UniProt Number: Q9H4Q4
05-1346
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1346
      DescriptionAnti-PRDM12 Antibody, clone 49AT1111.91.20
      Alternate Names
      • PR domain containing 12
      • PR domain-containing protein 12
      • PR-domain containing protein 12
      • PR-domain zinc finger protein 12
      Background InformationHistone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ1 is a tumor suppressor gene and the founding member of the PR domain family. PRDM12 (PR domain zinc finger protein 12) also acts as a tumor suppressor and is linked to the pathogenesis of chronic myeloid leukemia. PRDM12 is also thought to play a role in transcriptional regulation.
      References
      Product Information
      FormatPurified
      Control
      • 293 cells, rat spleen, mouse lymph node, and rat thymus tissue lysates.
      PresentationPurified monoclonal antibody supplied in PBS with 0.09% (weight/volume) sodium azide.
      Applications
      ApplicationAnti-PRDM12 Antibody, clone 49AT1111.91.20 is a Mouse Monoclonal Antibody for detection of PRDM12 also known as PR-domain zinc finger protein 12 & has been validated in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesELISA:
      This antibody is reported by an outside laboratory to be suitable for ELISA.
      Biological Information
      ImmunogenThis antibody was raised using purified recombinant GST fusion protein encoding human PRDM12.
      Clone49AT1111.91.20
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes human PRDM12.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteRat. Very weak reactivity seen in mouse tissue.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PFM9
      • OTTHUMP00000022367
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: May be involved in transcriptional regulation.

      SUBCELLULAR LOCATION: NucleusPotential.

      SIMILARITY: Contains 3 C2H2-type zinc fingers.

      Contains 1 SET domain.
      Molecular Weight~41 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis:
      The antibody detects PRDM12 by Western blot in rat spleen, mouse lymph node (weakly), and rat thymus cell lysates. Also detected PRDM12 in human 293 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      05-1346 04053252282317

      Documentation

      Anti-PRDM12 Antibody, clone 49AT1111.91.20 Certificates of Analysis

      TitleLot Number
      Anti-PRDM12 - NG1593370 NG1593370

      References

      Reference overviewPub Med ID
      A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.
      Reid, A G and Nacheva, E P
      Leukemia, 18: 178-80 (2004)  2004

      		14523459 14523459
      Quantitative PCR identifies a minimal deleted region of 120 kb extending from the Philadelphia chromosome ABL translocation breakpoint in chronic myeloid leukemia with poor outcome.
      Kolomietz, E, et al.
      Leukemia, 17: 1313-23 (2003)  2003

      		12835719 12835719
      SET domains and histone methylation.
      Xiao, Bing, et al.
      Curr. Opin. Struct. Biol., 13: 699-705 (2003)  2003

      		14675547 14675547
      The yin-yang of PR-domain family genes in tumorigenesis.
      Jiang, G L and Huang, S
      Histol. Histopathol., 15: 109-17 (2000)  2000

      Show Abstract       		10668202 10668202

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies