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580550 InSolution™ Tautomycetin, S. griseochromogenes

InSolution™ Tautomycetin, S. griseochromogenes MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TMC, TC

580550
  
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      Overview

      Replacement Information
      Description
      OverviewA cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC50 = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC50 ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo.
      Catalogue Number580550
      Brand Family Calbiochem®
      SynonymsTMC, TC
      References
      ReferencesMitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
      Product Information
      CAS number119757-73-2
      FormLiquid
      FormulationA 1 mM (50 µg/82 µl) solution in DMSO.
      Hill FormulaC₃₃H₅₀O₁₀
      Chemical formulaC₃₃H₅₀O₁₀
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPP1
      Primary Target IC<sub>50</sub>1.6 nM
      Secondary targetPP2A (IC₅₀ = 62 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSWX0900000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      580550 0

      Documentation

      InSolution™ Tautomycetin, S. griseochromogenes Certificates of Analysis

      TitleLot Number
      580550

      References

      Reference overview
      Mitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsTMC, TC
      DescriptionA cell-permeable Tautomycin (Cat. No. 580551) structural analog that acts as a selective PP1 inhibitor with ~38-fold greater potency compared to PP2A (IC50 = 1.6 nM for PP1 and 62 nM for PP2A). Inhibits LDP-1, PP2B, and PP5 only at much higher concentrations (IC50 ≥ 1 µM). Shown to completely inhibit intracellular PP1 activity at 5 µM without affecting PP2A in COS-7 cells. TMC is superior to Cyclosporin A (Cat. No. 239835) as a T cell immunosuppressor both in vitro and in vivo.
      FormLiquid
      FormulationA 1 mM (50 µg/82 µl) solution in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number119757-73-2
      RTECSWX0900000
      Chemical formulaC₃₃H₅₀O₁₀
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Flammable
      ReferencesMitsuhashi, S., et al. 2003. J. Biol. Chem. 278, 82. Shim, J.H., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 10617. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.