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17-370 SIRT1 Deacetylase-class III, NAD-dependent HDAC

SIRT1 is a class III, NAD-dependent histone deacetylase that is linked to ageing.

SIRT1 Deacetylase-class III, NAD-dependent HDAC MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Histone Deacetylase Assay (HDAC) UniProt Number: Q96EB6
17-370
1 kit  Kit capacity: Included in the kit is 50 micrograms of Sirt1 Deacetylase and 10 milligrams of β-nicotinamide adenine dinucleotide hydrate (#20-221).
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsEntrez Gene NumberSpeciesUni Prot Number
      HDACNM_012238.3 Human Q96EB6
      Description
      Catalogue Number17-370
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSIRT1 Deacetylase-class III, NAD-dependent HDAC
      OverviewSIRT1 is a class III, NAD-dependent histone deacetylase that is linked to ageing.
      References
      Product Information
      Applications
      ApplicationSIRT1 is a class III, NAD-dependent histone deacetylase that is linked to ageing.
      Key Applications
      • Histone Deacetylase Assay (HDAC)
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.
      Gene Symbol
      • SIRT1
      • hSIR2
      • SIR2alpha
      • SIR2L1
      • OTTHUMP00000060745
      • hSIRT1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96EB6 # NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2- mediated transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity is either weak or inexistent in vivo. In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein.
      COFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 747 amino acids; 81681 Da
      SUBUNIT: Interacts with TAF1B. Found in a complex with PCAF and MYOD1 (By similarity). Interacts with MLLT7/FOXO4, HES1, HEY2, p53/TP53 and PML.
      SUBCELLULAR LOCATION: Nucleus. Note=Recruited to the nuclear bodies via its interaction with PML.TISSUE SPECIFICITY: Widely expressed.
      SIMILARITY: SwissProt: Q96EB6 ## Belongs to the sirtuin family. & Contains 1 deacetylase sirtuin-type domain.
      MISCELLANEOUS: Red wine, which contains resveratrol, may participate in activation of sirtuin proteins, and may therefore participate in an extended lifespan as it has been observed in yeast.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evalauted by deacetylating assay substrate using the HDAC Assay Kit (#17-356).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size1 kit
      Material PackageKit capacity: Included in the kit is 50 micrograms of Sirt1 Deacetylase and 10 milligrams of β-nicotinamide adenine dinucleotide hydrate (#20-221).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade ITEM Number
      Catalogue Number GTIN
      17-370 04053252835704

      Documentation

      SIRT1 Deacetylase-class III, NAD-dependent HDAC Certificates of Analysis

      TitleLot Number
      SIRT1 Deacetylase - 0703056197 0703056197
      SIRT1 Deacetylase - 30079 30079
      SIRT1 Deacetylase - 30865 30865
      SIRT1 Deacetylase - 31837 31837
      Sirt1 Deacetylase - DAM1552991 DAM1552991

      References

      Reference overviewPub Med ID
      Hormonal control of androgen receptor function through SIRT1.
      Maofu Fu,Manran Liu,Anthony A Sauve,Xuanmao Jiao,Xueping Zhang,Xiaofang Wu,Michael J Powell,Tianle Yang,Wei Gu,Maria Laura Avantaggiati,Nagarajan Pattabiraman,Timothy G Pestell,Fang Wang,Andrew A Quong,Chenguang Wang,Richard G Pestell
      Molecular and cellular biology  26  2006

      Show Abstract Full Text Article      		16923962 16923962

      Brochure

      Title
      Shaping Epigenetics Discovery - Epigenetics Product Selection Brochure