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Dimethyl sulfoxide

Name: Dimethyl sulfoxide
Brand: MM

for headspace gas chromatography SupraSolv^®

Synonym(s):

Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO, DMSO

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About This Item

Linear Formula:

(CH₃)₂SO

CAS Number:

67-68-5

Molecular Weight:

78.13

UNSPSC Code:

12191502

NACRES:

NA.03

EC Index Number:

200-664-3

MDL number:

MFCD00002089

Beilstein/REAXYS Number:

506008

Assay:

≥99.8% (GC)

Technique(s):

GC-HS: suitable

Bp:

189 °C (lit.)

Vapor pressure:

0.42 mmHg ( 20 °C)

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Properties

Quality Segment

100

agency

according to Ph. Eur., according to USP

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

product line

SupraSolv^®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

573 °F

potency

28300 mg/kg LD₅₀, oral (Rat), 40000 mg/kg LD₅₀, skin (Rat)

expl. lim.

42 %, 63 °F

technique(s)

GC-HS: suitable

impurities

≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH, ≤0.05% Water

evapn. residue

≤3.0 mg/L

color

APHA: ≤10

refractive index

n20/D 1.479 (lit.)

kinematic viscosity

2.14 cSt

bp

189 °C (lit.)

mp

16-19 °C (lit.)

transition temp

flash point 87 °C

density

1.10 g/mL (lit.)

storage temp.

2-30°C

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Description

General description

SupraSolv^® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv^® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.

Application

SupraSolv^® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.

Features and Benefits

Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
Batch-to-batch consistency, ensuring reproducibility across analytical campaigns

Analysis Note

SupraSolv^® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:

Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
Class 3 solvents (low toxic potential): ≤ 50 µg/g

These specifications are verified lot-by-lot via GC/HS analysis, providing robust certification of compliance and analytical traceability.

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

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Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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