230790
Chymostatin
Selective neurokinin-1 (NK1) receptor antagonist, solid,powder
別名:
Chymostatin, [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A = Leu; B = Val; or C = Ile]-phenylalaninal
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この商品について
製品名
Chymostatin, Contains chymostatin "A" as a major form.
Quality Segment
description
RTECS - GC3047700
form
powder, solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white to slightly yellow
solubility
5% glacial acetic acid: 10 mg/mL, DMSO: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N7C(CCNC7=N)[C@H](NC(=O)N[C@@H](Cc9ccccc9)C(=O)O)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](Cc8ccccc8)C=O.N4C(CCNC4=N)[C@H](NC(=O)N[C@@H](Cc6ccccc6)C(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc5ccccc5)C=O.N1C(CCNC1=N)[C@H](NC(=O)N[C@@H](Cc3ccccc3)C(=O)O)C(=O)N[C@@
InChI
1S/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1
InChI key
QJIJPLFVFWXMGK-KSPFWWQASA-N
General description
Product does not compete with ATP.
Reversible: No
Chymostatin is a naturally occurring inhibitor of serine proteases with chymotryptic-like specificity. This tetrapeptide inhibitor is produced by various species of Streptomyces bacteria. Chymostatin is used as an inhibitor of MC chymase and is also capable of inhibiting several other proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, and lysosomal cysteine proteinases such as cathepsins B, H, andL. Itcontains chymostatin "A" as a major form.
Application
- cysteine protease inhibitor in thesubstrate to measure the activated FX (FXa) activity
- protease inhibitor in enzyme purificationlysis buffer
- protease inhibitor for ISW2 protein complexpurification
Legal Information
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable