Tetrabutylammonium chloride

Tetrabutylammonium chloride is a quaternary ammonium salt that is commonly used as a phase transfer catalyst as well as a source of chloride ions in organic synthesis.

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Tetrabutylammonium chloride (TBACl) can be used as a phase transfer catalyst in the synthesis of:

• 2-Amino-4H-chromene derivatives by the condensation reaction of aldehydes, malononitrile, and α, or β-naphthol.
• Methyl esters by esterification reaction of carboxylic acids with dimethyl carbonate in the presence of K₂CO₃.

It has also been used as an initiator to synthesize 11-trifluoromethylated dibenzodiazepines via cascade radical addition/cyclization of o-isocyanodiaryl amines.

TBACl can also be used with phosphorus pentoxide for greener deoxychlorination.

Process for Producing Halogenated Heteroaryl Compounds