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03-0164-00

SMC® Human IL-17F High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IL-17F in human serum and plasma

Synonym(s):

IL-17F Single Molecule Counting Kit, IL-17F ultra-sensitive immunoassay, IL17F immunoassay kit, Interleukin-17F immunoassay kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments
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Product Name

SMC® Human IL-17F High Sensitivity Immunoassay Kit,

description

Used for ultrasensitive quantification of Human IL-17F in human serum and plasma

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

Q96PD4

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

General description

Interleukin-17F (IL-17F) is a cytokine that belongs to the IL-17 family and is primarily produced by Th17 cells and other immune cells. It shares structural similarities with IL-17A and plays a role in promoting inflammatory responses, particularly in the context of autoimmune diseases and chronic inflammation. IL-17F is involved in the recruitment of neutrophils and the enhancement of pro-inflammatory cytokine production, contributing to the body′s defense against pathogens as well as the pathogenesis of various inflammatory conditions.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

  • Detect the Undectable: Detects IL-17F at concentrations as low as 200 fg/mL, enabling precise quantification of low-abundance cytokines in human plasma and serum.
  • Wide Dynamic Range: Standard curve spans 100-100,000 fg/mL, supporting both basal and elevated IL-17F levels in diverse sample types.
  • Advance Th17 Pathway Research: IL-17F is a critical cytokine in autoimmune and inflammatory diseases such as asthma, psoriasis, and IBD. This assay supports mechanistic studies and therapeutic development.
  • Enable Early Biomarker Discovery: Detect subclinical cytokine shifts with high sensitivity, ideal for identifying early disease markers and monitoring immune responses.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 200 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 100-100,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 99% Plasma: 101%
  • Recovery: Serum: 94% Plasma: 105%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although IL-17F was detectable in non-human primate samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

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