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PHR1655

Carbidopa

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O4 · H2O
CAS Number:
38821-49-7
Molecular Weight:
244.24
NACRES:
NA.24
PubChem Substance ID:
329823533
UNSPSC Code:
41116107
MDL number:
MFCD00889211
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1095506, traceable to Ph. Eur. C0460000

API family

carbidopa

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O

InChI

1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1

InChI key

QTAOMKOIBXZKND-PPHPATTJSA-N

Gene Information

human ... DDC(1644)

General description

Carbidopa is a peripheral decarboxylase inhibitor which is often formulated with levodopa for the management of the symptoms of Parkinson′s disease. Its mode of action involves the reduction of systemic production of dopamine and minimization of undesirable effects such as nausea.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA5756 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

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This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

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Simultaneous estimation of levodopa and carbidopa by RP-HPLC using a fluorescence detector: its application to a pharmaceutical dosage form
Raut PP and Charde SY
Luminescence, 29(7), 762-771 (2014)
Stability-indicating method for the determination of levodopa, levodopa-carbidopa and related impurities
Kafil JB and Dhingra BS
Journal of Chromatography A, 667(1-2), 175-181 (1994)
Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3, 4-dihydroxyphenyl acetic acid
Karimi M, et al.
Journal of Chromatography. B, Biomedical Applications, 836(1-2), 120-123 (2006)
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