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S6942

Staurosporine solution from Streptomyces sp.

Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)

Synonym(s):

Antibiotic AM-2282

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
200-664-3
MDL number:
MFCD04041131
Assay:
>98% (HPLC)
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Product Name

Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)

Quality Segment

300

assay

>98% (HPLC)

concentration

1 mM in DMSO (100 μg/214 μL)

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

General description

Chemical structure: indol derivative

Application

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4

Biochem/physiol Actions

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Storage Class

10 - Combustible liquids

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

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