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524403 Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem

A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM).

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na

Primary Target: AMG-CoA reductase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
81131-70-6C₂₃H₃₅O₇.Na

Products

Catalogue NumberPackaging Qty/Pack
524403-25MGCN Plastic Bag(s) 25 mg
Description
OverviewA water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
Catalogue Number524403
Brand Family Calbiochem®
Synonyms(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
References
ReferencesKwak, B., et al. 2000. Natl. Med. 6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
Product Information
CAS number81131-70-6
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₂₃H₃₅O₇.Na
Chemical formulaC₂₃H₃₅O₇.Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
Biological Information
Primary TargetAMG-CoA reductase
Primary Target K<sub>i</sub>~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQJ7185000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Environmental Hazard
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
524403-25MGCN 04055977270983

Documentation

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem Certificates of Analysis

TitleLot Number
524403

References

Reference overview
Kwak, B., et al. 2000. Natl. Med. 6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-May-2008 RFH
Synonyms(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
DescriptionA water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (Ki ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number81131-70-6
RTECSQJ7185000
Chemical formulaC₂₃H₃₅O₇.Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Environmental Hazard
Merck USA index14, 7714
ReferencesKwak, B., et al. 2000. Natl. Med. 6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179