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219381 Cathepsin K Inhibitor III - Calbiochem

The Cathepsin K Inhibitor III controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Cathepsin K Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂

Primary Target: Cathepsin K
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₄₃N₇O₆

Products

Catalogue NumberPackaging Qty/Pack
219381-1MGCN 玻璃瓶 1 mg
Description
OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
Catalogue Number219381
Brand Family Calbiochem®
SynonymsInhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂
References
ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
Product Information
ATP CompetitiveN
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₀H₄₃N₇O₆
Chemical formulaC₃₀H₄₃N₇O₆
Hygroscopic Hygroscopic
ReversibleY
Quality SegmentMQ100
Applications
Biological Information
Primary TargetCathepsin K
Primary Target K<sub>i</sub>9.7 nM against cathepsin K
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
219381-1MGCN 04055977201642

Documentation

Cathepsin K Inhibitor III - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Cathepsin K Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
219381

References

Reference overview
Wang, D., et al. 2002. Biochemistry 41, 8849.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-June-2008 RFH
SynonymsInhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂
DescriptionA cell-permeable, potent, selective, reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.
FormLyophilized white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₄₃N₇O₆
Peptide SequenceH-Phe-Leu-NHNH-CO-NHNH-Leu-Z
Purity≥97% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.