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509272 Hydroxychloroquine Sulfate - CAS 747-36-4 - Calbiochem

A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC₅₀ = 30 µM).

Hydroxychloroquine Sulfate - CAS 747-36-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HCQ, Autophagy Inhibitor

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
747-36-4C₁₈H₂₈ClN₃O₅S

Products

Catalogue NumberPackaging Qty/Pack
5.09272.0001 玻璃瓶 25 mg
Description
OverviewA cell-permeable, orally available quinoline derivative with anti-malarial properties. Increases intralysosomal pH and thereby impairs autophagic degradation process. Reduces metabolic activity and suppresses proliferation of human dermal fibroblasts (IC50 = 30 µM). Shown to inhibit ERK1/2 phosphorylation (Thr202/Try204), but does not affect Akt and mTOR phosphorylation. Shown to directly block the binding of CXCL12 to CXCR4 and inhibit downstream effects in pancreatic cancer cells (EC50 = 9.8 µM). Effectively antagonizes CXCR4-mediated cell proliferation in PANC-1, Hs-766T, and MIAPaCa-2 cells. Suppresses Toll-like receptor 9 (TLR-9)-mediated dendritic cell activation and displays anti-inflammatory properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509272
Brand Family Calbiochem®
SynonymsHCQ, Autophagy Inhibitor
References
ReferencesKim, J., et al. 2012. PLoS ONE. 7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
Kuznik, A., et al. 2011. J. Immunol. 186, 4794.
Product Information
CAS number747-36-4
FormOff-white powder
Hill FormulaC₁₈H₂₈ClN₃O₅S
Chemical formulaC₁₈H₂₈ClN₃O₅S
Structure formula ImageStructure formula Image
Quality SegmentMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36/37/39

Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade ITEM Number
Catalogue Number GTIN
5.09272.0001 04055977241754

Documentation

Hydroxychloroquine Sulfate - CAS 747-36-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Hydroxychloroquine Sulfate - CAS 747-36-4 - Calbiochem Certificates of Analysis

TitleLot Number
509272

References

Reference overview
Kim, J., et al. 2012. PLoS ONE. 7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
Kuznik, A., et al. 2011. J. Immunol. 186, 4794.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-February-2014 JSW
SynonymsHCQ, Autophagy Inhibitor
DescriptionA cell-permeable, orally available quinoline derivative with anti-malarial properties. Increases intralysosomal pH and thereby impairs autophagic degradation process. Reduces metabolic activity and suppresses proliferation of human dermal fibroblasts (IC50 = 30 µM). Shown to inhibit ERK1/2 phosphorylation (Thr202/Try204), but does not affect Akt and mTOR phosphorylation. Shown to directly block the binding of CXCL12 to CXCR4 and inhibit downstream effects in pancreatic cancer cells (EC50 = 9.8 µM). Effectively antagonizes CXCR4-mediated cell proliferation in PANC-1, Hs-766T, and MIAPaCa-2 cells. Suppresses Toll-like receptor 9 (TLR-9)-mediated dendritic cell activation and displays anti-inflammatory properties.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number747-36-4
Chemical formulaC₁₈H₂₈ClN₃O₅S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesKim, J., et al. 2012. PLoS ONE. 7, e31004.
Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
Kuznik, A., et al. 2011. J. Immunol. 186, 4794.