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860355P

Avanti

16:0 PC-d62

Avanti Research™ - A Croda Brand

Sinónimos:

1,2-dipalmitoyl-d62-sn-glycero-3-phosphocholine

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Fórmula empírica (notación de Hill):
C40H18NO8PD62
Número CAS:
25582-63-2
Peso molecular:
796.42
MDL number:
MFCD00151588
UNSPSC Code:
12352100
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
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Nombre del producto

16:0 PC-d62, Avanti Research™ - A Croda Brand 860355P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (860355P-10mg), pkg of 1 × 100 mg (860355P-100mg), pkg of 1 × 200 mg (860355P-200mg), pkg of 1 × 25 mg (860355P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860355P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)COC(C([2H])([2H

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1/i1D3,2D3,6D2,7D2,8D2,9D2,10D2,11D2,12D2,13D2,14D2,15D2,16D2,17D2,18D2,19D2,20D2,21D2,22D2,23D2,24D2,25D2,26D2,27D2,28D2,29D2,30D2,31D2,32D2,33D2

InChI key

KILNVBDSWZSGLL-PWXLRKPBSA-N

General description

16:0 PC-d62 is a deuterated phosphocholine (PC) in which 62 protons of dipalmitoyl are replaced by deuterium.
Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

Application

16:0 PC-d62 may be used for the preparation of asymmetric large unilamellar vesicles (aLUVs) for use as cell membrane models.

Packaging

5 mL Amber Glass Screw Cap Vial (860355P-100mg)
5 mL Amber Glass Screw Cap Vial (860355P-10mg)
5 mL Amber Glass Screw Cap Vial (860355P-200mg)
5 mL Amber Glass Screw Cap Vial (860355P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Clase de almacenamiento

11 - Combustible Solids

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Certificados de análisis (COA)

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Preparation of asymmetric phospholipid vesicles for use as cell membrane models
Doktorova M, et al.
Nature Protocols, 13(9), 2086-2101 (2018)
Kalliopi-Kelli A Vandera et al.
Molecular pharmaceutics, 17(7), 2354-2369 (2020-05-01)
Gram-negative bacteria possess numerous defenses against antibiotics, due to the intrinsic permeability barrier of their outer membrane (OM), explaining the recalcitrance of some common and life-threatening infections. We report the formulation of a new drug, PPA148, which shows promising activity
Drew Marquardt et al.
Langmuir : the ACS journal of surfaces and colloids, 33(15), 3731-3741 (2017-01-21)
We measured the transbilayer diffusion of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in large unilamellar vesicles, in both the gel (Lβ') and fluid (Lα) phases. The choline resonance of headgroup-protiated DPPC exchanged into the outer leaflet of headgroup-deuterated DPPC-d13 vesicles was monitored using 1H
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