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PHR1724

Haloperidol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Haloperidol, 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone, 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone, 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone

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Fórmula empírica (notación de Hill):
C21H23ClFNO2
Número CAS:
52-86-8
Peso molecular:
375.86
NACRES:
NA.24
PubChem Substance ID:
329823577
UNSPSC Code:
41116107
EC Number:
200-155-6
MDL number:
MFCD00051423
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Quality Segment

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. H0100000, traceable to USP 1303002

API family

haloperidol

CofA

current certificate can be downloaded

packaging

pkg of 400 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3

InChI

1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChI key

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Haloperidol is a major tranquilizer that is indicated for the treatment of schizophrenia, mania and neurological disorders including hyperkinesia.

Application

Haloperidol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC) and spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7792 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque los certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto, justo después de las palabras «Lote» o «Batch».

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Quantitative high performance liquid chromatographic determination of bamipine combined with tricyclic antidepressants and/or antipsychotics in pharmaceutical formulations.
Kountourellis JE, et al.
Analytical Letters, 26(10), 2171-2182 (1993)
Validation of derivative spectrophotometry method for determination of active ingredients from neuroleptics in pharmaceutical preparations.
Stolarczyk M, et al.
Acta Poloniae Pharmaceutica, 66(4), 351-356 (2009)
Determination and degradation study of haloperidol by high performance liquid chromatography.
Trabelsi H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 649-657 (2002)