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Merck

PHR1258

Chloroquine phosphate

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Chloroquine diphosphate salt, N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

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Fórmula empírica (notación de Hill):
C18H26ClN3 · 2H3PO4
Número CAS:
50-63-5
Peso molecular:
515.86
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823259
EC Number:
200-055-2
Beilstein/REAXYS Number:
4223142
MDL number:
MFCD00069852

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InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

biological source

synthetic

grade

certified reference material, pharmaceutical secondary standard

agency

EP, USP, traceable to USP 1118000

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

chloroquine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

storage condition

protect from light

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to yellow

pH

3.5-4.5 (10% in aqueous solution, pH <6.0)

mp

200 °C (dec.) (lit.)

solubility

water: 50 g/L, benzene: practically insoluble, chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Chloroquine phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin-layer chromatography (TLC) and liquid chromatography (LC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Chloroquine phosphate is a phosphate salt of chloroquine. It belongs to the class of aminoquinoline drugs utilized as antimalarials and amebicides.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3715 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Rapid spectrofluorimetric determination of chloroquine phosphate tablets
Nelson O, et al.
International Journal of Drug Development and Research, 2(2), 412-417 (2010)
Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine
Sahraei Z, et al.
International Journal of Antimicrobial Agents, 105945(10.1016) (2020)
Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography
Abdelrahman AN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 12(2), 205-208 (1994)
Kazuhito Sasaki et al.
Anti-cancer drugs, 23(7), 675-682 (2012-05-09)
Autophagy is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemotherapy. Recently, chloroquine diphosphate (CQ), a widely used antimalarial drug, has been studied as a potential inhibitor of autophagy.
David Tordrup et al.
Malaria journal, 10, 15-15 (2011-01-25)
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together
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