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Merck

PHR1394

Fluoxetina hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

(±)-N-metil-γ-[4-(trifluorometil)fenoxi]bencenopropanamina hydrochloride, LY-110,140 hydrochloride, Prozac®

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Fórmula empírica (notación de Hill):
C17H18F3NO · HCl
Número CAS:
56296-78-7
Peso molecular:
345.79
NACRES:
NA.24
PubChem Substance ID:
329823368
UNSPSC Code:
41116107
EC Number:
260-101-2
MDL number:
MFCD00214288

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InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

SMILES string

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

grade

certified reference material, pharmaceutical secondary standard

agency

USP 1279804, traceable to Ph. Eur. F0253000

API family

fluoxetine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SLC6A4(6532)

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Categorías relacionadas

Biochem/physiol Actions

Inhibidor selectivo de la recaptación de serotonina; antidepresivo.

Legal Information

Se vende bajo licencia de Eli Lilly and Company.
Prozac is a registered trademark of Eli Lilly and Co.

Application

Fluoxetine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluoxetine Hydrochloride is a selective serotonin-reuptake inhibitor used as an antidepressant. It is also utilized for the treatment of obsessive-compulsive disorders.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAC3045 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Quality assessment of internet pharmaceutical products using traditional and non-traditional analytical techniques
Westenberger BJ, et al.
International Journal of Pharmaceutics, 306(1), 56-70 (2005)
Simultaneous RP-HPLC and HPTLC Estimation of Fluoxetine Hydrochloride and Olanzapine in Tablet Dosage Forms
Patel S and Patel NJ
Indian Journal of Pharmaceutical Sciences, 71(4), 477-477 (2009)
Brunno Rocha Levone et al.
Neurobiology of stress, 14, 100331-100331 (2021-05-18)
Current antidepressants are suboptimal due incomplete understanding of the neurobiology underlying their behavioral effects. However, imaging studies suggest the hippocampus is a key brain region underpinning antidepressant action. There is increasing attention on the functional segregation of the hippocampus into
Screening methods for impurities in multi-sourced fluoxetine hydrochloride drug substances and formulations
Wirth DD, et al.
Chromatographia, 46(9-10), 511-511 (1997)
Determination of fluoxetine hydrochloride enantiomeric excess using high-performance liquid chromatography with chiral stationary phases
Olsen BA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 17(4), 623-630 (1998)
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