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C4915

S-(+)-Chlorpheniramine maleate salt

Name: <I>S</I>-(+)-Chlorpheniramine maleate salt
Brand: SIGMA

Sinónimos:

(S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt

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Fórmula empírica (notación de Hill):

C₁₆H₁₉ClN₂ · C₄H₄O₄

Número CAS:

2438-32-6

Peso molecular:

390.86

NACRES:

NA.77

PubChem Substance ID:

24278317

UNSPSC Code:

12352116

EC Number:

219-450-6

MDL number:

MFCD00079046

Form:

powder

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Propiedades

form

powder

Quality Segment

200

originator

Bayer

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

InChI key

DBAKFASWICGISY-DASCVMRKSA-N

Gene Information

human ... HRH1(3269)

Descripción

General description

Chlorpheniramine maleate is a cationic amphiphilic anti-histamine agent, which is composed of a hydrophobic ring structure and a hydrophilic side chain with a charged cationic amino group.

Application

S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle.

Biochem/physiol Actions

H₁ histamine receptor antagonist; active isomer.
Chlorpheniramine maleate is clinically used as a topical ointment to treat skin disorders such as sunburn, urticaria, angioedema, pruritus and insect bites.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.