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P5514

Pyrilamine maleate salt

Name: Pyrilamine maleate salt
Brand: SIGMA

Sinónimos:

Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt

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Fórmula empírica (notación de Hill):

C₁₇H₂₃N₃O · C₄H₄O₄

Número CAS:

59-33-6

Peso molecular:

401.46

NACRES:

NA.77

PubChem Substance ID:

24277797

UNSPSC Code:

12352116

EC Number:

200-422-7

MDL number:

MFCD00069333

Form:

powder

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Propiedades

form

powder

Quality Segment

100

originator

Watson

SMILES string

OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

InChI

1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

JXYWFNAQESKDNC-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

Descripción

Application

Pyrilamine maleate salt has been used:

to treat Cassiopea sp. as H₁ receptor antagonist
to intraperitoneally inject mice to prevent the release of endogenous histamine
in membrane binding assay to determine the K_i values and in the comparative inhibitory concentration (IC₅₀) studies by whole-cell patch clamp technique

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.