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A5376

Acetylsalicylic acid

Name: Acetylsalicylic acid
Brand: SIGMA

≥99.0%

Sinónimos:

2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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Fórmula lineal:

2-(CH₃CO₂)C₆H₄CO₂H

Número CAS:

50-78-2

Peso molecular:

180.16

UNSPSC Code:

12352106

NACRES:

NA.21

PubChem Substance ID:

24278218

EC Number:

200-064-1

Beilstein/REAXYS Number:

779271

MDL number:

MFCD00002430

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Propiedades

biological source

synthetic

Quality Segment

200

assay

≥99.0%

form

powder

color

white

pKa (25 °C)

3.5

mp

134-136 °C (lit.)

solubility

H₂O: 10 mg/mL at 37 °C(lit.), H₂O: 3 mg/mL at 25 °C(lit.), ethanol: 50 mg/mL, aqueous base: decomposes

ε (extinction coefficient)

190 at 298 nm in aqueous base at 1 mM, 409 at 231 nm in aqueous base at 1 mM, 466 at 230 nm in aqueous acid at 1 mM, 68 at 278 nm in aqueous acid at 1 mM

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743)

Descripción

General description

Acetylsalicylic acid is an organic compound commonly referred to as aspirin. It works by blocking the production of compounds in the body that cause pain, swelling, and fever. Acetylsalicylic acid also serves a vital function in preventing blood clots from forming in the arteries. In research, acetylsalicylic acid is studied for its role in oxidative stress, and in cancer research as a biomarker.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.