C0166
Cys-Gly
≥85% (TLC), suitable fo HPLC
Sinónimos:
L-cysteinyl-glycine
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Fórmula empírica (notación de Hill):
C5H10N2O3S
Número CAS:
Peso molecular:
178.21
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
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Permítanos ayudarleNombre del producto
Cys-Gly, ≥85% (TLC)
SMILES string
NC(CS)C(=O)NCC(O)=O
InChI
1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)
InChI key
ZUKPVRWZDMRIEO-UHFFFAOYSA-N
assay
≥85% (TLC)
form
solid
technique(s)
HPLC: suitable
storage temp.
−20°C
Quality Level
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Categorías relacionadas
Application
Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).
Biochem/physiol Actions
Cys-Gly is a precursor for glutathione biosynthesis in the neurons. It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.
L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.
General description
Cys-Gly, a dipeptide is a catabolic byproduct of glutathione.
Other Notes
Glutathione fragment
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(28), 3400-3404 (2009-06-30)
A fully automated HPLC method for the simultaneous determination of total thiols in plasma samples has been developed. The method involves reductive conversion of disulfides to their reduced counterparts with the use of tris(2-carboxyethyl)phosphine. After reduction the newly formed sulfhydryl
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Dringen R, et al.
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Cappiello M, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1560-1565 (2016)
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 911, 15-20 (2012-12-12)
Alterations in the plasma aminothiols levels can be considered as important biomarkers for the diagnosis and screening of several human disorders, namely cardiovascular diseases. We aimed to optimize a rapid, sensitive and accurate RP-HPLC methodology with fluorescence detection, for the
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