Glucose is a critical component of many cell culture media and is generally regarded as a high-risk raw material for viral contamination. This high-risk designation arises from the plant origin source (sugarcane or beet fields) coupled with its innate attractiveness to virus-carrying rodents. HTST (High Temperature Short Time) pasteurization of glucose enables robust clearance of viruses with high physico-chemical resistance, and provides a point-of-origin solution to mitigate the risk of viral contamination in high-risk cell culture components.
Treatment of high-risk materials such as glucose with HTST brings peace of mind without compromising cell culture performance.
We have expanded our HTST pasteurization capabilities and can provide HTST-treated glucose, manufactured under an ISO9001:2015 comprehensive Quality Management System, to global markets. This application note describes how HTST pasteurization can provide viral contamination risk mitigation for large volume, high-risk raw materials such as glucose, without impacting feed viability or cell culture performance.
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High Temperature Short Time (HTST) treated glucose
HTST pasteurization is a highly effective method to inactivate viruses.