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Merck

W218405

Butylated hydroxytoluene

≥99%, FCC, FG

Synonym(s):

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
128-37-0
Molecular Weight:
220.35
E Number:
E 321
PubChem Substance ID:
24900896
UNSPSC Code:
12164502
FEMA Number:
2184
NACRES:
NA.21
EC Number:
204-881-4
MDL number:
MFCD00011644
Beilstein/REAXYS Number:
1911640
Organoleptic:
camphoraceous
Grade:
FG, Fragrance grade, Kosher
Biological source:
synthetic
Agency:
follows IFRA guidelines
Food allergen:
no known allergens

Key Documents

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InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

biological source

synthetic

grade

FG, Fragrance grade, Kosher

agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009, EU Regulation 1333/2008 & 178/2002, FCC, FDA 21 CFR 117, FDA 21 CFR 172.115

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

assay

≥99%

form

powder or crystals

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

camphoraceous

Quality Level

300, 400

Gene Information

human ... CAPN1(823)
rat ... Capn1(29153), Nos1(24598)

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General description

Butylated hydroxytoluene is a synthetic phenolic compound mainly used as an antioxidant and preservative in the food industry. It is used to prevent the lipid oxidation in oils and fat-containing foods.

Application


  • Role of odorant binding protein C12 in the response of Tribolium castaneum to chemical agents.: This article explores the impact of BHT on insect biochemistry, specifically how it affects the binding affinity of odorant-binding proteins in pests, providing insights into developing more effective pest control strategies (Wang et al., 2024).

  • A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3-nitropropionic acid in in vitro and in vivo models.: Research includes BHT as a comparative standard in studying neuroprotective agents, underscoring its role in biochemical pathways related to oxidative stress and neuroprotection (Campos et al., 2024).

  • Simultaneous Determination of Fipronil, Permethrin and their Key Related Substances in a Topical Drug Product by a Single Stability Indicating High Performance Liquid Chromatography Method.: BHT is used as an internal standard to assess the stability and integrity of pharmaceutical products, demonstrating its utility in pharmaceutical analysis (Rathnasekara et al., 2024).

  • Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in the development of antidiabetic drugs via inhibition of a-amylase and DPP4 activity.: This study utilizes BHT as a reference antioxidant to compare the efficacy of newly synthesized compounds, providing a benchmark in antioxidant research for diabetes treatment (Chahal et al., 2024).

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Storage Class

11 - Combustible Solids

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Hazard Classifications

Aquatic Chronic 1

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Certificates of Analysis (COA)

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Burdock GA
Encyclopedia of Food and Color Additives, 1, 327-330 (1997)
Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives
Williams GM, et al.
Food And Chemical Toxicology, 37(9), 1027-1038 (1999)
Safety aspects of food preservatives
Parke DV & Lewis DFV
Food Additives and Contaminants, 9(5), 561-577 (1992)
Silvia Carvajal et al.
Scientific reports, 9(1), 12848-12848 (2019-09-08)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized
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