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Merck

49779

Glycerol

greener alternative

tested according to Ph. Eur., anhydrous

Synonym(s):

Glycerolum, 1,2,3-Propanetriol, Glycerin

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About This Item

Linear Formula:
HOCH2CH(OH)CH2OH
CAS Number:
Molecular Weight:
92.09
UNSPSC Code:
12191502
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-289-5
Beilstein/REAXYS Number:
635685
MDL number:
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Quality Level

agency

tested according to Ph. Eur.

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

form

liquid

autoignition temp.

698 °F

greener alternative product characteristics

Safer Solvents and Auxiliaries
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

refractive index

n20/D 1.474 (lit.)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

density

1.25 g/mL (lit.)

greener alternative category

SMILES string

OCC(O)CO

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

General description

Glycerol is odourless, colorless, viscous in nature, and exists as a sweet tasting liquid. It can be derived naturally as well as from petrochemical feedstock. Glycerol has a wide variety of applications, and is one of the most valuable and versatile chemical substances in nature. It can be used as an emollient, solvent, sweetening agent, in pharmaceutical formulations, cosmetics, foodstuffs and toiletries. It is very stable and can be easily stored under normal temperature; also it is non-irritating and has no adverse impact to the environment.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. Glycerol, with its high boiling point, low flammability, and polarity, is a standout choice. As a non-toxic and biodegradable compound, it aligns perfectly with the principles of ′Safer Solvents and Auxiliaries′ and ′Design for Degradation′. Click here for more information.

Application

Glycerol has been used as
  • a supplement during cell culture of Mycobacterium tuberculosis and Mycobacterium avium.
  • a fuel during designing enzymatic biofuel cell.
  • a liquid composite matrix with 4-HCCA and 3-amino­quinoline for analysis of neutral and acidic glycans.
  • a matrix for fast atom bombardment MS.
  • may be employed as liquid matrix for the quantification studies by MALDI (Matrix-assisted laser desorption/ionization mass spectrometry) analysis.

Biochem/physiol Actions

Glycerol is hygroscopic in nature and is soluble in water owing to its three hydrophilic alcoholic hydroxyl groups. It can form both inter- and intramolecular hydrogen bonds, making it a very flexible molecule. The physiologic effect of glycerine is due to cell-mediated immunity, increased IgG production and increased histamine release.


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Storage Class

10 - Combustible liquids

flash_point_f

390.2 °F - Pensky-Martens closed cup

flash_point_c

199 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves



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The mechanism of the protective action of glycerol against haemolysis by freezing and thawing.
J E LOVELOCK
Biochimica et biophysica acta, 11(1), 28-36 (1953-05-01)
Nafiseh Masoumi et al.
Journal of biomedical materials research. Part A, 101(1), 104-114 (2012-07-25)
Microfabricated poly(glycerol sebacate) (PGS) scaffolds may be applicable to tissue engineering heart valve leaflets by virtue of their controllable microstructure, stiffness, and elasticity. In this study, PGS scaffolds were computationally designed and microfabricated by laser ablation to match the anisotropy
Hovsep Mahdessian et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8913-8918 (2014-06-14)
Genome-wide association studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) concentration and nonalcoholic fatty liver disease. However, the identity and functional role of the gene(s) responsible for these associations remain unknown. Of 19 expressed genes