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Merck

D2158

Histodenz™

nonionic density gradient medium

Synonym(s):

5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide

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About This Item

Empirical Formula (Hill Notation):
C19H26I3N3O9
CAS Number:
66108-95-0
Molecular Weight:
821.14
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24893646
EC Number:
266-164-2
Beilstein/REAXYS Number:
2406632
MDL number:
MFCD00077732

Key Documents

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Product Name

Histodenz™, nonionic density gradient medium

InChI key

NTHXOOBQLCIOLC-UHFFFAOYSA-N

InChI

1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

SMILES string

CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I

form

powder

application(s)

hematology
histology

storage temp.

room temp

Quality Level

200

Related Categories

Application

HistoDenz™ is suitable for separating everything from macromolecules to viable cells by either rate-zonal or isopycnic centrifugation.
  • It has been used in the isolation and culturing of hepatic stellate cells.
  • It has also been employed in the extraction of microbial cells from environmental samples.
  • It has been used in LacZ (β-galactosidase) staining.
  • It has also been used for the enrichment of gonocytes.

Features and Benefits

HistoDenz™ offers several favorable properties as a gradient medium.
  • It has very low toxicity, low osmolality, high density, and low viscosity (compared to sucrose).
  • It is water-soluble, non-ionic, and chemically near-inert.

General description

HistoDenz™, also known as iohexol, is a non-ionic X-ray contrast compound developed specifically as an iodinated density gradient medium.

Legal Information

Histodenz is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD6617V
WXBD5584V
WXBD3838V
WXBD1108V
WXBD2400V

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Extraction of Microbial Cells from Environmental Samples for FISH Approaches
Jennifer Pratscher
Methods in Molecular Biology, 2246 (2021)
Attachment of Pseudomonas putida onto differently structured kaolinite minerals: A combined ATR-FTIR and 1H NMR study.
Vasiliadou I A, et al.
Colloids and Surfaces. B, Biointerfaces, 84(2), 354-359 (2011)
Malin Helenius et al.
Scandinavian journal of urology, 49(5), 377-381 (2015-03-21)
Computed tomography urography (CTU) can be used to direct further investigation of patients if the bladder tumour detection rate is high. The aim of this study was to compare a CTU protocol including an enhancement-triggered scan and flexible cystoscopy for
Skeletal muscle tissue clearing for lacz and fluorescent reporters, and immunofluorescence staining.
Verma M, et al.
Methods in Molecular Biology, 129-140 (2016)
Optimization of culture conditions for short-term maintenance, proliferation, and colony formation of porcine gonocytes.
Awang-Junaidi, et al.
Journal of Animal Science and Biotechnology, 9(1), 8-8 (2018)
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