E1257
Epidermal Growth Factor from murine submaxillary gland
lyophilized powder, BioReagent, suitable for cell culture
Synonym(s):
EGF, Epidermal cell growth factor
biological source
mouse submaxillary glands
product line
BioReagent
assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
0.02-2.0 ng/mL EC50
packaging
pkg of 0.1 mg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
white
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
mouse ... Egf(13645)
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Analysis Note
The biological activity is measured in a proliferation assay using BALB/MK cells.
Application
Epidermal Growth Factor from murine submaxillary gland has been used
- in studying its effects on the development of caustic esophageal stricture in rats
- for preparation of MCF-10A cell line
- for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)
Biochem/physiol Actions
Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.
General description
Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.
Physical form
Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.
Preparation Note
Purified by gel filtration and ion-exchange chromatography.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Subcellular localization of epidermal growth factor receptor in human submandibular gland
Lantini MS, et al.
Journal of Anatomy, 208(5), 595-599 (2006)
High-sensitivity TFA-free LC-MS for profiling histones
You J, et al.
Proteomics, 11(16), 3326-3334 (2011)
Expression of epidermal growth factor in human tissues
Kajikawa K, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 418(1), 27-32 (1991)
Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
Koltuksuz U, et al.
Journal of Pediatric Surgery, 36(10), 1504-1509 (2001)
Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway
Zhang H, et al.
Biochimie, 127(21), 10-18 (2016)
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