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Merck

P0039

PHPS1 sodium salt hydrate

≥98% (HPLC)

Synonym(s):

4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C21H15N5O6S · xNa+ · yH2O
CAS Number:
314291-83-3
Molecular Weight:
465.44 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329819990
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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SMILES string

O=C1/C(C(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3)=N/NC4=CC=C(S(=O)([O-])=O)C=C4.[Na+].O

InChI

1S/C21H15N5O6S.Na.H2O/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16;;/h1-13,22H,(H,30,31,32);;1H2/q;+1;/p-1/b23-20+;;

InChI key

KLXUVMQUEDKCKG-JBKNFAMTSA-M

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

red

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Application

Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect in vivo and in vitro.

Biochem/physiol Actions

Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling.
Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling. The enzyme is expressed ubiquitously in mammalian tissues and plays essential roles in development. It is also implicated in various pathological states. PHPS1 is a selective inhibitor of Shp-2 and blocks Shp-2 dependent downstream signalling.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
017M4608V
092M4604V
059K46122
059K46121
059K4612

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Chunmei Fan et al.
Cell reports, 39(4), 110762-110762 (2022-04-28)
Tendon maturation lays the foundation for postnatal tendon development, its proper mechanical function, and regeneration, but the critical cell populations and the entangled mechanisms remain poorly understood. Here, by integrating the structural, mechanical, and molecular properties, we show that post-natal
Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.
Li J, Kang Y, Wei L, et al.
PLoS ONE, 9(7), e102847-e102847 (2014)

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