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P3510

Papaverine hydrochloride

Name: Papaverine hydrochloride
Brand: SIGMA

≥98% (titration by HCL04), powder, cerebral vasodilator

Synonym(s):

6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁NO₄ · HCl

CAS Number:

61-25-6

Molecular Weight:

375.85

NACRES:

NA.77

PubChem Substance ID:

24278152

UNSPSC Code:

41106305

EC Number:

200-502-1

MDL number:

MFCD00012745

Beilstein/REAXYS Number:

3921435

Assay:

≥98%

Form:

powder

Quality level:

100

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Properties

Product Name

Papaverine hydrochloride, powder

assay

≥98%

Quality Level

100

form

powder

color

white

solubility

H₂O: 25 mg/mL

SMILES string

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI key

UOTMYNBWXDUBNX-UHFFFAOYSA-N

Gene Information

human ... PDE4B(5142)

Description

General description

Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.

Application

Papaverine hydrochloride has been used:

in oxygenated Krebs solution for tissue mechanics analysis
as a vasodilator in heparinized horse serum in tissue uptake technique
as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

Biochem/physiol Actions

Papaverine is originally used to resolve male impotence.

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells

Grundemann D, et al.

British Journal of Pharmacology, 137(6), 910-918 (2002)

Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage

Liu James K and Couldwell William T

Neurocritical Care, 2(2), 124-132 (2005)

Increased glomerular albumin permeability in old spontaneously hypertensive rats

Bakoush O, et al.

Nephrology, Dialysis, and Transplantation, 19(7), 1724-1731 (2004)

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