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Merck

R4127

Rhodamine 6G

Dye content ~95 %, Powder

Synonym(s):

Basic Red 1

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About This Item

Linear Formula:
C28H31N2O3Cl
CAS Number:
989-38-8
Molecular Weight:
479.01
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24899367
EC Number:
213-584-9
MDL number:
MFCD00012665
Colour Index Number:
45160
Beilstein/REAXYS Number:
3900071

Key Documents

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Product Name

Rhodamine 6G, Dye content ~95 %

technique(s)

titration: suitable

mp

215 °C

solubility

H2O: 1 mg/mL (Red to Very Dark Red)

density

1.3 g/cm3

εmax

≥1700 at 525 nm in water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

InChI key

VYXSBFYARXAAKO-WTKGSRSZSA-N

InChI

1S/C28H30N2O3.ClH/c1-6-29-23-15-25-21(13-17(23)4)27(19-11-9-10-12-20(19)28(31)32-8-3)22-14-18(5)24(30-7-2)16-26(22)33-25;/h9-16,29H,6-8H2,1-5H3;1H/b30-24+;

SMILES string

Cl.CCNc1cc2OC3=CC(=N/CC)\C(C)=CC3=C(c2cc1C)c4ccccc4C(=O)OCC

form

powder

composition

Dye content, ~95%

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Application

Rhodamine 6G has been used as a leukocyte marker to study the interaction between leukocytes and the vascular endothelium. It has also been used to label platelets.

Biochem/physiol Actions

A rhodamine analog useful in Pgp efflux assays. Has been used to characterize kinetics of MRP1- mediated efflux.
Rhodamine 6G is a rhodamine analog useful in P-glycoprotein (Pgp) efflux assays. It has been used to characterize kinetics of multidrug resistance protein 1 (MRP1)-mediated efflux.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

989-38-8

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG0679
BCCG0678
BCCG0681
BCCC4671
BCCB3708

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Interaction of Kupffer Cells and Platelets Determines the Severity of Ischemia-Reperfusion Injury in Steatosis
Koichi Ogawa
The Tohoku Journal of Experimental Medicine, 232 (2014)
Kinetic Analysis of Rhodamines Efflux Mediated by the Multidrug Resistance Protein (MRP1)
Chantarawan S
Biophysical Journal, 85(3) (2003)
Discoidin Domain Receptor 1 Is a Major Mediator of Inflammation and Fibrosis in Obstructive Nephropathy
Dominique G
The American Journal of Pathology (2011)
Induction of P-Glycoprotein by Antiretroviral Drugs in Human Brain Microvessel Endothelial Cells
Gary N.Y. Chan
Antimicrobial Agents and Chemotherapy, 57(9) (2013)
Şefik E Erdener et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(2), 236-252 (2020-04-03)
Ever since the introduction of thrombolysis and the subsequent expansion of endovascular treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are less favorable despite recanalization. Here, by high spatio-temporal resolution imaging of capillary circulation
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