R8781
Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor
Synonym(s):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution
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About This Item
Empirical Formula (Hill Notation):
C51H79NO13
Molecular Weight:
914.17
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Product Name
Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
biological source
Streptomyces hygroscopicus
Quality Level
vapor pressure
0.56 hPa ( 20 °C)
assay
≥95% (HPLC)
form
solution
autoignition temp.
301 °C
concentration
2.5 mg/mL in DMSO (2.74 mM)
color
colorless to yellow
antibiotic activity spectrum
fungi, yeast
mode of action
enzyme | inhibits
storage temp.
−20°C
General description
Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.
Application
Rapamycin has been used:
- as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
- to treat the Drosophila S2 cells at 65-70% confluence,
- to measure protein synthesis
- to stimulate autophagy in ovarian cancer cells
Packaging
200uL
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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