220551
Chloramphenicol
Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.
Synonym(s):
Chloramphenicol
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About This Item
Empirical Formula (Hill Notation):
C11H12Cl2N2O5
CAS Number:
Molecular Weight:
323.13
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥97% (by Assay)
form
crystalline powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
gray to off-white
solubility
water: 2.5 mg/mL, methanol: 35 mg/mL, ethanol: soluble
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
InChI key
WIIZWVCIJKGZOK-UHFFFAOYSA-N
General description
Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.
Biochem/physiol Actions
Potency: ≥970 µg/mg
Primary Target
trasnslation of RNA
trasnslation of RNA
Other Notes
Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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Andrés Aranda-Díaz et al.
eLife, 9 (2020-01-30)
Predicting antibiotic efficacy within microbial communities remains highly challenging. Interspecies interactions can impact antibiotic activity through many mechanisms, including alterations to bacterial physiology. Here, we studied synthetic communities constructed from the core members of the fruit fly gut microbiota. Co-culturing