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Merck

C3130

Cortisone 21-acetate

synthetic (organic), ≥99%, corticosteroid, powder

Synonym(s):

17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate, 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione, 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H30O6
CAS Number:
Molecular Weight:
402.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-006-5
MDL number:
Beilstein/REAXYS Number:
2067543
Assay:
≥99%
Form:
powder
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Product Name

Cortisone 21-acetate, ≥99%

biological source

synthetic (organic)

sterility

non-sterile

assay

≥99%

form

powder

mp

237-240 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1

InChI key

ITRJWOMZKQRYTA-RFZYENFJSA-N

Gene Information

General description

Cortisone 21-acetate is a prodrug, which has glucocorticoid and mineralocorticoid properties. It is used as a therapeutic option for glucocorticoid replacement.

Application

Cortisone 21-acetate has been used to study its effects in metastasis and phagocytic activity.


pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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D M Dixon et al.
Infection and immunity, 57(5), 1452-1456 (1989-05-01)
We report on a model of primary pulmonary aspergillosis occurring after intranasal instillation of concentrated suspensions of conidia of Aspergillus fumigatus in immunocompromised mice. Unconcentrated suspensions of inoculum contained ca. 2 x 10(7) conidia per ml (1x). These suspensions were
Replacement therapy in Addison?s disease
Lovaas K and Husebye ES
Expert Opinion on Pharmacotherapy (2003)
Foye's Principles of Medicinal Chemistry (2008)