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E1631

β-Estradiol 17-valerate

Name: &#946;-Estradiol 17-valerate
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₂O₃

CAS Number:

979-32-8

Molecular Weight:

356.50

NACRES:

NA.77

PubChem Substance ID:

24894423

UNSPSC Code:

41116107

EC Number:

213-559-2

MDL number:

MFCD00056541

Beilstein/REAXYS Number:

2480357

Assay:

≥98%

Form:

powder

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Properties

Product Name

β-Estradiol 17-valerate, ≥98%

biological source

synthetic

Quality Segment

100

assay

≥98%

form

powder

technique(s)

ELISA: suitable

solubility

acetone: 25 mg/mL, hazy, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3

InChI key

RSEPBGGWRJCQGY-UHFFFAOYSA-N

Description

General description

β-Estradiol 17-valerate is a synthetic estrogen.

Application

β-Estradiol 17-valerate has been used:

in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Biochem/physiol Actions

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.